Type 2 diabetes mellitus is characterized by hyperglycemia insulin resistance and relative impairment in insulin secretion and its possible long term complications its pathogenesis is poorly understood but both genetic and environmental factors such as obesity and aging play a key role. Being overweight or obese increases the chances of developing the common type of diabetes type 2 diabetes in this disease the body makes enough insulin but the cells in the body have become resistant to the salutary action of insulin . Obesity represents the strongest modifiable risk factor for type 2 diabetes t2d obesity and t2d may develop on a common genetic risk background mechanisms linking obesity to t2d include abdominal fat distribution adipose tissue dysfunction and inflammation characterized by the secretion of a diabetogenic adipokine pattern which contributes to impaired insulin action in skeletal muscle liver brain and other organs in patients with obesity and t2d therapeutic weight reduction leads
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